Research &
Development
The focus of Genomix Biotech is to identify the crucial needs, explore the problems through fundamental research and develop best quality compounds or biopharmaceuticals for therapeutic intervention of disease processes.Genomix Biotech R& D team identified several crucial areas that are vital for not only for Indian subcontinent but also throughout the world health needs.
These areas of our research include:
Diagnostic kits for emerging diseases:
One of the major focus is to develop, produce and market immuno and molecular based diagnostic kits for different diseases.
Malaria: A series of genes from Plasmodium species are cloned and are expressed in different systems. A collaborative project to develop MDR malaria microarray chip with CDC is being developed.
MTB: Mycobacterium (MTB) genome has been used to isolate several structural genes including ESAT 6 recombinant protein that has great potentials for rapid diagnostic kits. A Collaborative project with University ofTexas medical School.
Bird flu: Five different genes from published sequences were synthesized and are used to generate synthetic genes for expression.
chikunguinya: Two viral lysates from India were used to purify total DNA and to isolate gene products for diagnostic kits and vaccines.
Dengue virus: Crude lysate was isolated from a diagnosed patient and will be used to generate gene products for diagnostic kits and vaccines.Diagnostic assays for critical products.
HIV: HIV is one of the major critical infectious disease and we are focusing to develop fourth generation Rapid diagnostic kits.Hb (S) Ag: Hepetitis B antigen based diagnostics assays.HCV antibody based assays
HIV Viral antigens: Recombinant proteins for HIV type 1 & 2 including gp 120, 39 kda and others will be expressed for diagnostic and research purposes. All the genomes are going to be used to generate recombinant proteins expressed in four different expression systems for generation of vaccines and rapid detection kits.
Cardiac Markers: Recombinant proteins and or specific antibodies will be used to detect and monitor cardiovascular diseases.
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ONGOING RESEARCH PROJECTS |
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S. No. |
Title of Project |
Source of Funds |
Amount |
Duration
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1. |
A venture towards translating the Indigenous diagnostic kits for economically important poultry viral diseases from lab to land |
BIRAC – PACE |
₹ 70.74 lakhs |
2020 (To be initiated) |
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2. |
Shielding Livestock from Paratuberculosis using Point of Care Diagnostics PoCD |
BIRAC – CRS |
₹ 79.66 lakhs |
2017 – 2020 |
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3. |
Scheduling Equines from Fatal Zoonotic disease- Glanders and Equine Infectious Anemia (EIA) in India using Point of Care Diagnostics (POCD) |
BIRAC – SBIRI |
₹ 68.40 lakhs |
2018 – 2020 |
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4. |
Developing rapid, sensitive, inexpensive, rapid and point of care diagnostic kits for canine diseases – Canine Leptospira, Canine Brucella, Canine Distemper and Canine Hepatitis |
DBT Network project |
₹ 34.76 lakhs |
2018 – 2021 |
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5. |
Development of field diagnostic tests for sero-monitoring of canine parvovirus vaccinated pups |
DBT Network project |
₹ 30.00 lakhs |
2018 – 2020 |
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6. |
Shielding the Livestock from Paratuberculosis using Vaccine: A Holistic Approach |
BIRAC – PACE |
₹ 35.00 lakhs |
2018 – 2020 |
R&D project proposed during the next three years |
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Title of project |
DBT – Brucella Free Village |
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Scope of project |
The project focuses towards the making of Indian villages devoid of Brucella infection by the means of awareness, vaccination and prevention of cross border transfers of animals. |
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Sponsoring Agency if any |
DBT, Govt. of India
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Project leader |
Dr. Rathnagiri Polavarapu (as Multicentric project)
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Title of project |
Development of field diagnostic tests for the monitoring of sexually transmitted diseases in cattle |
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Scope of project |
The project focuses towards the making of diagnostic kits for the diagnosis of STDs in Indian livestock. |
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Sponsoring Agency if any |
BIRAC |
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Project leader |
Dr. Rathnagiri Polavarapu |
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Title of project |
Development of isothermal thermal cycler (Amplite) instrument for LAMP to be used under field conditions |
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Scope of project |
The project focuses towards the usage of LAMP as the diagnostic tool to be used under field conditons |
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Sponsoring Agency if any |
BIRAC |
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Project leader |
Dr. Rathnagiri Polavarapu (in collaboration with Animal & Plant Health Agency, United Kingdom) |
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Title of project |
Utilisation of seaweed and sea waste as potential sources of fodder and materials of biomedical importance |
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Scope of project |
The project focuses towards utilization of sea weed as fodder for cattle, goats and sheep while the sea waste utilization for the preparation of materials of biomedical importance |
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Sponsoring Agency if any |
BIO-Nest under DBT, Govt. of India |
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Project leader |
Dr. Rathnagiri Polavarapu (in collaboration with Animal & Plant Health Agency, United Kingdom) |
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Title of project |
Development of field diagnostic tests for the detection of sexually transmitted diseases in cattle |
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Scope of project |
The project focuses towards the POC diagnostics towards the detection of Trypanosomiasis in livestock populations |
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Sponsoring Agency if any |
BIO-Nest under DBT, Govt. of India |
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Project leader |
Dr. Rathnagiri Polavarapu |